Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Integrative taxonomy unveils a new lineage within Acanthogonatus centralis Goloboff, 1995 (Araneae, Mygalomorphae, Pycnothelidae): description of Acanthogonatus monicae sp. nov. from central Argentina

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Integrative taxonomy unveils a new lineage within Acanthogonatus centralis Goloboff, 1995 (Araneae, Mygalomorphae, Pycnothelidae): description of Acanthogonatus monicae sp. nov. from central Argentina

Abstract

A new species of Pycnothelidae Chamberlin, 1917 from the Pampean mountain ranges, Córdoba, Argentina is described and illustrated: Acanthogonatus monicae sp. nov. Here, we combine morphological analyses, molecular phylogeny based on the COI gene, species delimitation methods (bPTP, ABGD), and ecological niche modeling. These approaches consistently support two independent evolutionary lineages previously assigned to A. centralis Goloboff, 1995. The new species is morphologically similar to A. centralis and A. parana Goloboff, 1995, but differs from both by genitalic characters in males and females. Additionally, an updated identification key for Argentine species of Acanthogonatus is provided.

Signorotto F, Ferretti N (2026) Integrative taxonomy unveils a new lineage within Acanthogonatus centralis Goloboff, 1995 (Araneae, Mygalomorphae, Pycnothelidae): description of Acanthogonatus monicae sp. nov. from central Argentina. Evolutionary Systematics 10(1): 31-46. https://doi.org/10.3897/evolsyst.10.172168