Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

First catalog of Salticidae (Arachnidae, Araneae) from French Guiana, with the description of one new species

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First catalog of Salticidae (Arachnidae, Araneae) from French Guiana, with the description of one new species

A work of bibliographic synthesis and identification of collected material made possible to complete the knowledge concerning one of the best studied spider families of the neotropical region from a systematic point of view, namely the Salticidae Blackwall, 1841. This catalog lists the presence of 122 species as well as 68 morphospecies, belonging to 36 genera, making a total of 190 potential species. After argument based on the observation of type species or individuals, exchanges with data producers or even verification of data in the bibliography, the following species, 19 in number, are deleted from the list of Salticidae of French Guyana: Amycus ectipus (Simon, 1900), Amycus pertyi Simon, 1900, Anasaitis canosa (Walckenaer, 1837), Chira simoni (Galiano, 1961), Chirothecia crassipes (Taczanowski, 1878), Colonus germaini (Simon, 1900), Corythalia tropica (Mello-Leitão, 1939), Hypaeus miles Simon, 1900, Lyssomanes amazonicus G. W. Peckham, E. G. Peckham & Wheeler, 1889, Lyssomanes elegans (Cambridge, 1900), Lyssomanes parallelus (Peckham & Wheeler, 1889), Matinta fasciata (Mello-Leitão, 1940), Noegus bidens (Simon, 1900), Noegus petrusewiczi Caporiacco, 1947, Psecas bubo (Taczanowski, 1871), Sarinda atrata (Taczanowski, 1871), Scopocira melanops (Taczanowski, 1871), Rudra wagae (Taczanowski, 1871) and Viciria chabanaudi Fage, 1923. The mention of a species in Vedel et al. (2013), not recognized by the World Spider Catalog (2023), is also deleted: Salticus fulvatus (Fabricius, 1896). The following new synonymy is established: Amycus flavolineatus C. L. Koch, 1846 is a junior synonym of Colonus sylvanus (Hentz, 1846), n. syn. Amycus amrishi Makhan, 2006 and Neonella heliophanina (Taczanowski, 1871) are considered as nomina dubia. Pseudopartona ornata Caporiacco, 1954, type species of the genus Pseudopartona Caporiacco, 1954 , belongs to the genus Sassacus Sassacus G. W. Peckham & E. G. Peckham, 1895, which results in Pseudopartona being synonymised with Sassacus, and the following new combination Sassacus ornatus (Caporiacco, 1954) n. comb. Finally, 25 species are newly cited, including one newly described species: Eustiromastix agatheae Courtial & Picard n. sp. (male).

COURTIAL C., PICARD L. & PÉTILLON J. 2025. — Premier catalogue des Salticidae (Arachnidae, Araneae) de Guyane et description d’une nouvelle espèce. Zoosystema 48 (4): 75-120. https://doi.org/10.5252/zoosystema2026v48a4. http://zoosystema.com/48/4