Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions

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  Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions Abstract Background:    Heterometrus laoticus and Lychas mucronatus are widely distributed in Southeast Asia, yet their pathophysiological effects of both venoms remain poorly characterized due to low human fatality rates. This study compared their venom compositions and acute cardiovascular and renal effects. Methods:   Anesthetized male New Zealand White rabbits were monitored for blood pressure (BP), heart rate (HR), and renal clearance following intravenous administration of crude venom (0.5 mg/kg). Venom components were identified via LC-MS/MS, and hematological/biochemical parameters were assessed. Results:    H. laoticus venom induced a rapid, transient hypotension ( p < 0.05), followed by a mild, prolonged hypotensive phase (up to 120 min). Conversely, L. mucronatus venom elicited a biphasic response: ...

The mitochondrial genome of Palpimanus capensis Simon, 1893 (Araneae, Palpimanidae) from ultraconserved elements (UCEs)

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The mitochondrial genome of Palpimanus capensis Simon, 1893 (Araneae, Palpimanidae) from ultraconserved elements (UCEs)

Abstract

The mitochondrial genome of Palpimanus capensis Simon, 1893 has been sequenced and annotated from ultraconserved elements (UCEs). The species is endemic to South Africa and is a free-living ground-dweller. Contigs were assembled in SPAdes, with a rough draft mitogenome extracted from the resulting contigs that was used as the seed for de novo assembly by NOVOPlasty for the final, circularized genome. The mitogenome was annotated using MITOS2 and by comparing it to other species in the order Araneae. The mitogenome is 14,268 bp, including 22 transfer RNA (tRNA), 13 protein coding genes (PCGs), 2 ribosomal RNA (rRNA) genes, and a control region. This is the first species in the genus Palpimanus and the family Palpimanidae with a sequenced and annotated mitochondrial genome.

Merrill, C. M., Patrick, L. B., Wood, H. M., & Santos, S. R. (2025). The mitochondrial genome of Palpimanus capensis Simon, 1893 (Araneae, Palpimanidae) from ultraconserved elements (UCEs). Mitochondrial DNA Part B, 10(12), 1221–1225. https://doi.org/10.1080/23802359.2025.2594315