Targeting snake venom metalloproteinases: structural diversity, molecular pathogenesis and therapeutic interventions

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  Targeting snake venom metalloproteinases: structural diversity, molecular pathogenesis and therapeutic interventions Abstract Snake venom Metalloproteinases (SVMPs) are Zn²⁺-dependent endopeptidases categorised under metzincin superfamily and are predominantly found in venom of the “ Viperidae ” family snakes. They are key mediators of venom-induced pathology with associated tissue damage including haemorrhage and oedema. SVMPs are classified as P-I, P-II, and P-III depending on the domains, each differing in structural complexity and organization. Further, the conserved HEXXHXXGXXH catalytic motif organizes a Zn 2+ ion, essential for the breakdown of peptide bonds and proteins. Given the limitations of conventional antivenom therapy, increasing attention has been directed toward targeted approaches for SVMPs neutralization, including plant-derived phytocompounds, synthetic and repurposed small-molecule inhibitors, recombinant monoclonal antibodies, and camelid-derived nanobodi...

The genus Harpactea Bristowe, 1939 (Araneae, Dysderidae) from the Jijel region (Algeria), with the description of a new species

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The genus Harpactea Bristowe, 1939 (Araneae, Dysderidae) from the Jijel region (Algeria), with the description of a new species

Abstract

Harpactea jijelensis sp. nov. (♂♀) is described from Jijel, north-east Algeria. The new species is assigned to the corticalis species group and the auriga subgroup, based on the distinctive characteristics of the male. A detailed description, along with diagnostic characters, and illustrations of the genitalia for both sexes are provided. Additionally, information on the species’ abundance, and distribution across various habitats in the region is presented. New distribution records for Harpactea acuta Beladjal & Bosmans 1997 and Harpactea innupta Beladjal & Bosmans 1997 are presented.

Kahlessenane, S., Bouseksou, S., Kherbouche-Abrous, O., Moulaï, R., Bosmans, R. & Beladjal, L. (2025) The genus Harpactea Bristowe, 1939 (Araneae, Dysderidae) from the Jijel region (Algeria), with the description of a new species. Zootaxa, 5719 (3), 440–450. https://doi.org/10.11646/zootaxa.5719.3.10