Targeting snake venom metalloproteinases: structural diversity, molecular pathogenesis and therapeutic interventions

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  Targeting snake venom metalloproteinases: structural diversity, molecular pathogenesis and therapeutic interventions Abstract Snake venom Metalloproteinases (SVMPs) are Zn²⁺-dependent endopeptidases categorised under metzincin superfamily and are predominantly found in venom of the “ Viperidae ” family snakes. They are key mediators of venom-induced pathology with associated tissue damage including haemorrhage and oedema. SVMPs are classified as P-I, P-II, and P-III depending on the domains, each differing in structural complexity and organization. Further, the conserved HEXXHXXGXXH catalytic motif organizes a Zn 2+ ion, essential for the breakdown of peptide bonds and proteins. Given the limitations of conventional antivenom therapy, increasing attention has been directed toward targeted approaches for SVMPs neutralization, including plant-derived phytocompounds, synthetic and repurposed small-molecule inhibitors, recombinant monoclonal antibodies, and camelid-derived nanobodi...

The genome sequence of a running crab spider, Tibellus oblongus (Walckenaer, 1802) (Araneae: Philodromidae)

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The genome sequence of a running crab spider, Tibellus oblongus (Walckenaer, 1802) (Araneae: Philodromidae)

Abstract

We present a genome assembly from an individual female Tibellus oblongus (running crab spider; Arthropoda; Arachnida; Araneae; Philodromidae). The assembly contains two haplotypes with total lengths of 3 189.47 megabases and 3 294.81 megabases. Of haplotype 1 and haplotype 2, 99.03% and 91.65% of the sequence, respectively, are scaffolded into 13 chromosomal pseudomolecules, including X1 and X2. The mitochondrial genome has also been assembled, with a length of 14.37 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

Sivell O, Henriques S, Natural History Museum Genome Acquisition Lab et al. The genome sequence of a running crab spider, Tibellus oblongus (Walckenaer, 1802) (Araneae: Philodromidae) [version 1; peer review: awaiting peer review]. Wellcome Open Res 2025, 10:651 (https://doi.org/10.12688/wellcomeopenres.25198.1)