Acute gonadal toxicity induced by Bothrops atrox venom in mice

Posted by
  Acute gonadal toxicity induced by Bothrops atrox venom in mice Abstract Bothrops atrox is responsible for most snakebite incidents in the Amazon region. Its venom is recognized for causing significant tissue damage and systemic effects. However, its effect on reproductive organs remains poorly explored. This study aimed to investigate the acute effects of B. atrox venom on testes and ovaries of adult mice. Male and female mice were exposed to B. atrox venom (½ LD 50 ) via four administration routes subcutaneous (SC), intramuscular (IM), intravenous (IV), and intraperitoneal (IP), followed by comprehensive assessment of gonadal histology, sperm function, oxidative stress biomarkers, antioxidant enzyme activities, and mRNA expression of inflammatory and apoptotic markers. Following B. atrox venom exposure, ovarian histological architecture remained preserved across all routes, whereas testicular tissue exhibited route-dependent injury ranging from moderate luminal apoptosis aft...

The genome sequence of a running crab spider, Tibellus oblongus (Walckenaer, 1802) (Araneae: Philodromidae)

Posted by

 

The genome sequence of a running crab spider, Tibellus oblongus (Walckenaer, 1802) (Araneae: Philodromidae)

Abstract

We present a genome assembly from an individual female Tibellus oblongus (running crab spider; Arthropoda; Arachnida; Araneae; Philodromidae). The assembly contains two haplotypes with total lengths of 3 189.47 megabases and 3 294.81 megabases. Of haplotype 1 and haplotype 2, 99.03% and 91.65% of the sequence, respectively, are scaffolded into 13 chromosomal pseudomolecules, including X1 and X2. The mitochondrial genome has also been assembled, with a length of 14.37 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

Sivell O, Henriques S, Natural History Museum Genome Acquisition Lab et al. The genome sequence of a running crab spider, Tibellus oblongus (Walckenaer, 1802) (Araneae: Philodromidae) [version 1; peer review: awaiting peer review]. Wellcome Open Res 2025, 10:651 (https://doi.org/10.12688/wellcomeopenres.25198.1)