AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

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  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

Two new species of the spider wasps genus Morochares Banks, 1934 (Hymenoptera: Pompilidae) from China

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Two new species of the spider wasps genus Morochares Banks, 1934 (Hymenoptera: Pompilidae) from China

Abstract

Morochares storozhenkoi Loktionov, sp. nov. and M. liuxi Loktionov, sp. nov. are described and illustrated from Guangdong, China. These are the seventh and eighth known species of the genus, and the sixth and seventh from China. An updated key to the Chinese species is given.

Loktionov, V.M. (2025) Two new species of the spider wasps genus Morochares Banks, 1934 (Hymenoptera: Pompilidae) from China. Zootaxa, 5715 (1), 244–250. https://doi.org/10.11646/zootaxa.5715.1.22