Predation of Latrodectus tredecimguttatus (Rossi, 1790) (Araneae: Theridiidae) on two lizard species, Ablepharus chernovi (Darevski, 1953) and Anatololacerta finikensis (Eiselt & Schmidtler, 1987), in the Antalya Province of Turkey

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  Predation of Latrodectus tredecimguttatus (Rossi, 1790) (Araneae: Theridiidae) on two lizard species, Ablepharus chernovi (Darevski, 1953) and Anatololacerta finikensis (Eiselt & Schmidtler, 1987), in the Antalya Province of Turkey Abstract For the first time, two lizard species were found partially consumed by the same Mediterranean black widow and at an altitude of around 1800 msnm, marking a notable increase in predation altitude compared to previous records. The present observation bolsters the hypothesis that lizard predation by L. tredecimguttatus may be more prevalent than previously reported, and emphasizes the need for further studies to better understand the dietary habits of this species, particularly in mountainous regions.  Gomard, Guillaume. (2026). Predation of Latrodectus tredecimguttatus (Rossi, 1790) (Araneae: Theridiidae) on two lizard species, Ablepharus chernovi (Darevski, 1953) and Anatololacerta finikensis (Eiselt & Schmidtler, 1987), in the An...

Functional and Immunological Variability of Viperid Venoms Across Continents and Cross-Neutralization by Peruvian Antivenoms

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Functional and Immunological Variability of Viperid Venoms Across Continents and Cross-Neutralization by Peruvian Antivenoms

Abstract

Snake envenomation remains a significant neglected tropical disease primarily treated with antivenoms, which, despite inherent limitations, continue to be the gold standard therapy. Snake venoms exhibit extensive compositional and functional diversity, posing challenges for universal antivenom efficacy. This study comprehensively evaluated venom composition, enzymatic activities, and immunological cross-reactivity across 24 Viperidae species from diverse geographic regions. Using protein profiling, enzymatic assays (proteolytic, amidolytic, clotting, and PLA2 activities), and phylogenetic analyses, we revealed marked interspecific variation. Bothrops species exhibited elevated SVMP-driven proteolytic activity, while Crotalus venoms demonstrated more balanced enzymatic profiles. Phylogenetic clustering highlighted evolutionary divergence and functional convergence among taxa. Immunoreactivity assays with Peruvian antibothropic, anticrotalic, and antilachesic antivenoms showed broad cross-recognition within Bothrops and Crotalus venoms, but limited efficacy against more distantly related Viperinae species. Western blot analyses confirmed these specificity patterns. Neutralization assays revealed differential inhibition: antibothropic antivenom effectively neutralized proteolytic activity, whereas anticrotalic antivenom preferentially inhibited PLA2-mediated effects. This functional variability highlights the biochemical complexity of viperid venoms and the constraints of current antivenoms. Our findings emphasize the urgent need to develop improved, broadly effective antivenom formulations capable of targeting the diverse toxin profiles of geographically and phylogenetically distinct viperid species, ultimately enhancing clinical management of snakebite envenomation worldwide.
Torrejón, D., Llontop, A., Proléon, A., Lazo, F., Urra, F. A., Yarlequé, A., & Vivas-Ruiz, D. E. (2025). Functional and Immunological Variability of Viperid Venoms Across Continents and Cross-Neutralization by Peruvian Antivenoms. Biochimie. https://doi.org/10.1016/j.biochi.2025.10.013