Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions

Posted by
  Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions Abstract Background:    Heterometrus laoticus and Lychas mucronatus are widely distributed in Southeast Asia, yet their pathophysiological effects of both venoms remain poorly characterized due to low human fatality rates. This study compared their venom compositions and acute cardiovascular and renal effects. Methods:   Anesthetized male New Zealand White rabbits were monitored for blood pressure (BP), heart rate (HR), and renal clearance following intravenous administration of crude venom (0.5 mg/kg). Venom components were identified via LC-MS/MS, and hematological/biochemical parameters were assessed. Results:    H. laoticus venom induced a rapid, transient hypotension ( p < 0.05), followed by a mild, prolonged hypotensive phase (up to 120 min). Conversely, L. mucronatus venom elicited a biphasic response: ...

Scorpion Venom Gland Transcriptomics: A Systematic Review

Posted by

 


Scorpion Venom Gland Transcriptomics: A Systematic Review

Abstract

Scorpion venom is a complex biochemical arsenal with significant ecological and biomedical importance. Advances in transcriptomic techniques have provided valuable insights into the composition and functional diversity of venoms. This systematic review analyzes transcriptomic research conducted between 2010 and 2024, focusing on methodologies such as Expressed Sequence Tags (ESTs) and Next-Generation Sequencing (NGS). 42 studies from four databases (Scopus, PubMed, Web of Science, and ScienceDirect) were selected, showcasing their impact on detecting venom-related transcripts. The classification of venom components revealed a diverse range of bioactive molecules, including ion channel toxins, enzymes, antimicrobial peptides, and uncharacterized components with potential therapeutic applications. The findings emphasize the importance of multi-omic approaches in elucidating venom complexity and the potential applications of novel components in pharmacology and biotechnology. However, significant challenges remain, including the need for standardization and expanded research on underrepresented taxa. This review highlights the necessity for interdisciplinary efforts to bridge these gaps and fully harness the potential of scorpion venom studies.
Solano-Godoy, J. A., Betancourt-Osorio, M., Orjuela-Rodriguez, M., Guerrero-Vargas, J. A., & Sepulveda-Arias, J. C. (2025). Scorpion Venom Gland Transcriptomics: A Systematic Review. Toxicon, 108563. https://doi.org/10.1016/j.toxicon.2025.108563