Letter: Description of Two Cases of Spider Bites Attributed to Loxosceles rufescens (Araneae, Sicariidae) in Albania

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  Letter: Description of Two Cases of Spider Bites Attributed to Loxosceles rufescens (Araneae, Sicariidae) in Albania Fewer than 0.5% of spider species are medically significant, with the genus  Loxosceles  responsible for most dermonecrotic envenomings. 1 , 2  In the Mediterranean,  Loxosceles rufescens  is the primary species associated with loxoscelism. 2  This synanthropic spider thrives in human dwellings, typically biting only when inadvertently provoked. 1 , 3 , 4  Its venom, containing sphingomyelinase D, triggers local inflammation and necrosis, 1 , 5  and rarer the acute localized exanthematous pustulosis. 6  Diagnosis is often challenged by initial painlessness, leading to frequent misidentification as bacterial infections. 2 , 4 , 5  These cases in Albania highlight the need for improved clinical recognition of regional spider-bite occurrences. 7 Two cases were retrospectively documented via interviews and photos. Infor...

Scorpion Venom Gland Transcriptomics: A Systematic Review

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Scorpion Venom Gland Transcriptomics: A Systematic Review

Abstract

Scorpion venom is a complex biochemical arsenal with significant ecological and biomedical importance. Advances in transcriptomic techniques have provided valuable insights into the composition and functional diversity of venoms. This systematic review analyzes transcriptomic research conducted between 2010 and 2024, focusing on methodologies such as Expressed Sequence Tags (ESTs) and Next-Generation Sequencing (NGS). 42 studies from four databases (Scopus, PubMed, Web of Science, and ScienceDirect) were selected, showcasing their impact on detecting venom-related transcripts. The classification of venom components revealed a diverse range of bioactive molecules, including ion channel toxins, enzymes, antimicrobial peptides, and uncharacterized components with potential therapeutic applications. The findings emphasize the importance of multi-omic approaches in elucidating venom complexity and the potential applications of novel components in pharmacology and biotechnology. However, significant challenges remain, including the need for standardization and expanded research on underrepresented taxa. This review highlights the necessity for interdisciplinary efforts to bridge these gaps and fully harness the potential of scorpion venom studies.
Solano-Godoy, J. A., Betancourt-Osorio, M., Orjuela-Rodriguez, M., Guerrero-Vargas, J. A., & Sepulveda-Arias, J. C. (2025). Scorpion Venom Gland Transcriptomics: A Systematic Review. Toxicon, 108563. https://doi.org/10.1016/j.toxicon.2025.108563