Could venom-derived therapeutics resolve treatment resistance in refractory EAC?

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  Could venom-derived therapeutics resolve treatment resistance in refractory EAC? Abstract The incidence of esophageal adenocarcinoma is rising in Western countries. Despite advances in chemotherapy and immunotherapy, the prognosis remains poor, with an overall 5-year survival rate below 15%. A major challenge is the cancer’s poor and often unpredictable response to current treatments. Animal venoms represent a promising yet underexplored source of therapeutic agents, offering millions of structurally diverse and highly potent bioactive peptides that can modulate a wide array of molecular targets. However, only a small fraction of these peptides has been pharmacologically characterized. This review presents the therapeutic potential of venom-derived peptides in cancer treatment, summarizes the role of ion channels in esophageal adenocarcinoma (EAC), and discusses peptides targeting ion channels that may offer new opportunities for future EAC treatment. Freuville L, Matthys C, Gill...

On the taxonomic validity of Indian ground spiders: VI. Genera Ladissa Simon, 1907, Melicymnis Simon, 1885, and Poecilochroa Westring, 1874 (Araneae: Gnaphosidae)

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On the taxonomic validity of Indian ground spiders: VI. Genera Ladissa Simon, 1907, Melicymnis Simon, 1885, and Poecilochroa Westring, 1874 (Araneae: Gnaphosidae)

Abstract

Indian species of the genera Ladissa Simon, 1907, Melicymnis Simon, 1885, and Poecilochroa Westring, 1874 are reviewed. The species Ladissa latecingulata Simon, 1907, and Melicymnis bicolor Simon, 1885 are considered as species inquirenda due to the immature stage of the types. The type locality of L. latecingulata is confirmed as in Pakistan, and its record in India is found incorrect. The following new combinations are recognised: Hitobia behni (Thorell, 1891) comb. nov., H. devendrai (Gajbe & Rane, 1985) comb. nov. and H. tikaderi (Patel, 1989) comb. nov. (all ex. Poecilochroa). Images of all the examined type specimens, and supplementary descriptions for P. barmani, H. behni comb. nov. and H. devendrai comb. nov. are presented.

Sankaran, P.M. & Caleb, J.T. (2025) On the taxonomic validity of Indian ground spiders: VI. Genera Ladissa Simon, 1907, Melicymnis Simon, 1885, and Poecilochroa Westring, 1874 (Araneae: Gnaphosidae). Zootaxa, 5673 (1), 132–142. https://doi.org/10.11646/zootaxa.5673.1.9