AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

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  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

Mygalomorph Spiders (Araneae: Mygalomorphae) from Chile: General Aspects and First Identification Key for Families

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Mygalomorph Spiders (Araneae: Mygalomorphae) from Chile: General Aspects and First Identification Key for Families

Abstract

This article provides a key for identifying the families of mygalomorph spiders known in Chile. It also reviews general aspects of each family, such as morphological characteristics, geographic distribution, natural history and diversity.

Montenegro Vargas, R. ., & Aguilera, M. A. . (2025). Arañas migalomorfas (Araneae: Mygalomorphae) de Chile: aspectos generales y primera clave de identificación para familias. Revista Chilena De Entomología, 51(3). Retrieved from https://www.biotaxa.org/rce/article/view/87624