Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization

Posted by
  Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization Abstract Pathological corneal neovascularization remains a major therapeutic challenge due to the limited efficacy and safety of currently available antiangiogenic treatments. Although C-type lectins from snake venom possess various biological activities, their potential to modulate pathological ocular angiogenesis has not been explored. This study investigated the antiangiogenic effects of Leuculectin, a C-type lectin isolated from Bothrops leucurus venom using an experimental model of corneal neovascularization (CNV), a HUVEC (human umbilical vein endothelial cell) tube formation assay, and the chick embryo chorioallantoic membrane (CAM) assay. In the HUVEC tube formation assay, Leuculectin demonstrated strong antiangiogenic activity. In the CAM assay, Leuculectin applied at concentrations of 1.5, 2.5 and 3.5 μg/mL significantly decreased new ves...

Four new species of Linyphiidae spiders (Arachnida: Araneae) from Jiangjin District of Chongqing, China

Posted by

 


Four new species of Linyphiidae spiders (Arachnida: Araneae) from Jiangjin District of Chongqing, China

Abstract

An ongoing survey on spider diversity in Jiangjin District, Chongqing City has the goal of documenting the regional diversity of spiders. In this context, we here describe four new species of the spider family Linyphiidae from Jiangjin District of Chongqing: Gonatium tridentatum sp. nov. (♂♀), Oedothorax simianensis sp. nov. (♂), Wuliphantes dahonghaiensis sp. nov. (♂♀) and Yuelushannus baishaensis sp. nov. (♂). Detailed descriptions, photographs of copulatory organs and somatic features are presented. Additionally, color photos of Ceratinella brevis (Wider, 1834) (♂) and distribution map of all five species are provided.

Irfan, M., Zhang, C.-C., Cai, Y.-J. & Zhang, Z.-S. (2025) Four new species of Linyphiidae spiders (Arachnida: Araneae) from Jiangjin District of Chongqing, China. Zootaxa, 5647 (5), 435–450. https://doi.org/10.11646/zootaxa.5647.5.2