Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies

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  Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies Abstract Despite advances in cancer therapeutics, there are still challenges in improving drug toxicity and selectivity. Peptides from various venous species have recently garnered attention for their biopharmaceutical potential, particularly in cancer. The present study aimed to conduct a meta-analysis of the antitumor activity of scorpion venom-derived peptides (SVDPs) previously reported in preclinical models. The bibliographic research included original and review articles written in English published from 2015 to 2026. Studies within the scope were retrieved from the EBSCO Discovery Service, PubMed, and WIPO databases. A total of 27 articles that met the inclusion and exclusion criteria were included in this research, and the collected data were synthesized through a meta-analysis. In the included in vitro and in vivo studies, the effect of SVDPs on breast/mammary gland, cervical,...

Assessment of Ecosystem Sustainability and Management Measures in the Danube Floodplains in Slovakia by the Bioindicative Value of Spiders (Araneae)

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Assessment of Ecosystem Sustainability and Management Measures in the Danube Floodplains in Slovakia by the Bioindicative Value of Spiders (Araneae)

Abstract

The aim of this research was to record changes in the population structure of epigeic spider assemblages in the Central European Danube Delta (Slovakia) as a result of habitat management measures and the impact of human intervention. During this research (2020–2023), we assessed the impact of management measures on newly planted forest stands and the effect of grazing in semi-natural conditions, and carried out diversity monitoring in flooded meadows. A total of 6344 individuals belonging to 89 spider species were collected by pitfall traps and identified. Using spatial modelling, we observed the following: (i) there are differences between the structures of managed and unmanaged forest stands (larger number of taxa); (ii) the differences in the number of individuals between study plots and years were statistically significant; (iii) the trend analysis of spider communities showed that study plots that underwent management intervention are expected to see an increase in the number of individuals in the future; and (iv) in the areas that did not undergo management, the number of species was stable. Using spiders as bioindicators could therefore answer the question of whether anthropogenic disturbance disrupts ecological stability. This approach utilizes spiders to assess the sustainability of the landscape.

Krumpálová, Z., & Langraf, V. (2025). Assessment of Ecosystem Sustainability and Management Measures in the Danube Floodplains in Slovakia by the Bioindicative Value of Spiders (Araneae). Forests, 16(6), 1027. https://doi.org/10.3390/f16061027