Scorpion Venom Peptides: Novel Therapeutic Approaches for Inflammatory and Hepatic Disorders

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  Scorpion Venom Peptides: Novel Therapeutic Approaches for Inflammatory and Hepatic Disorders Abstract Chronic hepatic disorders, such as metabolic dysfunction associated steatohepatitis (MASH), alcohol associated liver disease (ALD), and viral hepatitis (Hepatitis B Virus [HBV]/Hepatitis C Virus [HCV]), are primarily driven by persistent immune-mediated inflammation and hepatic stellate cell activation leading to fibrosis, yet conventional therapies lack tissue and molecular specificity. Scorpion venom peptides, refined through evolutionary selection, provide highly potent, target specific scaffolds capable of modulating intrahepatic inflammatory networks. Recent in vivo preclinical studies indicate that voltage gated potassium (Kv1.3) channel blocking peptides, such as BmKK2, significantly reduce macrophage activation and inhibit downstream cytokine production, effectively ameliorating diet-induced steatohepatitis and tissue scarring in murine models. Engineered hepatotropic ca...

A new species of Chaerilus Simon, 1877 from Pakistan (Scorpiones: Chaerilidae)

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A new species of Chaerilus Simon, 1877 from Pakistan (Scorpiones: Chaerilidae)

Abstract

A new species belonging to the genus Chaerilus Simon, 1877 is described from northern Pakistan. The new species is morphologically compared with the geographically closest species occurring in northern Pakistan, northern India and Nepal. This new taxon represents the 60th described species among the currently recognized species for the genus Chaerilus.

Eric Ythier, Wilson R Lourenço. A new species of Chaerilus Simon, 1877 from Pakistan (Scorpiones: Chaerilidae).. Faunitaxys, 2025, 13 (27), pp.1-6. ⟨10.57800/faunitaxys-13(27)⟩. ⟨hal-05133644⟩