AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

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  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

A new species of Chaerilus Simon, 1877 from Pakistan (Scorpiones: Chaerilidae)

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A new species of Chaerilus Simon, 1877 from Pakistan (Scorpiones: Chaerilidae)

Abstract

A new species belonging to the genus Chaerilus Simon, 1877 is described from northern Pakistan. The new species is morphologically compared with the geographically closest species occurring in northern Pakistan, northern India and Nepal. This new taxon represents the 60th described species among the currently recognized species for the genus Chaerilus.

Eric Ythier, Wilson R Lourenço. A new species of Chaerilus Simon, 1877 from Pakistan (Scorpiones: Chaerilidae).. Faunitaxys, 2025, 13 (27), pp.1-6. ⟨10.57800/faunitaxys-13(27)⟩. ⟨hal-05133644⟩