Variability of sodium channel toxins in Mesobuthus thersites Advised toolkit for comprehensive venomics

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Variability of sodium channel toxins in Mesobuthus thersites Advised toolkit for comprehensive venomics Abstract Natural venoms constitute vast combinatorial libraries of ion channel ligands with unprecedented properties including high affinity and selectivity. Scorpion venoms in particular are abundant in sodium and potassium channel ligands representing small proteins or peptides, which are traditionally studied by transcriptomics and proteomics approaches. However, a universal algorithm to pursue the examination of multicomponent peptide-rich mixtures such as venoms is lacking. Here we present a general scheme to the analysis of scorpion toxin arsenal with focus on sodium channel ligands. We explored the venom of the Central Asian scorpion Mesobuthus thersites using venom gland transcriptomics and three proteomic methods. We compared traditional automated annotation by Blast2GO with our custom approach based on regular expressions. We found that the traditional annotation is compro...

Invertebrate venoms: A treasure trove of bioactive compounds with anticancer potential

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Invertebrate venoms: A treasure trove of bioactive compounds with anticancer potential

Abstract

Invertebrate venoms, despite their inherent toxicity, represent a promising source of bioactive compounds with significant anticancer properties. Historically, traditional medicines in Asia, Africa, and other regions have utilized these venoms to treat a variety of diseases, particularly those derived from scorpions, bees, wasps, and cone snails. Contemporary research has illuminated their therapeutic potential, especially in oncology. In vitro and in vivo studies demonstrate that specific toxins from these venoms can inhibit tumor cell proliferation, induce apoptosis, and restrict metastasis. The anticancer efficacy of invertebrate venoms is primarily attributed to their capacity to selectively target malignant cells while minimizing adverse effects on healthy tissues. In addition, bioactive compounds extracted from certain invertebrate venoms exhibit selective cytotoxicity against various cancer cell lines and can inhibit enzymes critical to tumor progression, thereby impeding the invasion and dissemination of cancerous cells. The increasing interest in the application of invertebrate venoms in cancer therapy has spurred further investigations into their therapeutic potential. This review critically evaluates recent scientific advancements concerning the anticancer properties of bioactive molecules derived from invertebrate venoms, elucidating their mechanisms of action and efficacy across different cancer types. We emphasize their potential as viable alternatives or adjuncts to conventional therapies, which are often constrained by their associated toxicity.

Lafnoune, A., Chbel, A., Darkaoui, B. et al. Invertebrate venoms: A treasure trove of bioactive compounds with anticancer potential. Arch Toxicol (2025). https://doi.org/10.1007/s00204-025-04032-0