Variability of sodium channel toxins in Mesobuthus thersites Advised toolkit for comprehensive venomics

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Variability of sodium channel toxins in Mesobuthus thersites Advised toolkit for comprehensive venomics Abstract Natural venoms constitute vast combinatorial libraries of ion channel ligands with unprecedented properties including high affinity and selectivity. Scorpion venoms in particular are abundant in sodium and potassium channel ligands representing small proteins or peptides, which are traditionally studied by transcriptomics and proteomics approaches. However, a universal algorithm to pursue the examination of multicomponent peptide-rich mixtures such as venoms is lacking. Here we present a general scheme to the analysis of scorpion toxin arsenal with focus on sodium channel ligands. We explored the venom of the Central Asian scorpion Mesobuthus thersites using venom gland transcriptomics and three proteomic methods. We compared traditional automated annotation by Blast2GO with our custom approach based on regular expressions. We found that the traditional annotation is compro...

A niche modeling approach to unveil the absence of pycnothelid spiders (Mygalomorphae: Pycnothelidae) in a mountainous grassland of central Argentina

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A niche modeling approach to unveil the absence of pycnothelid spiders (Mygalomorphae: Pycnothelidae) in a mountainous grassland of central Argentina

ABSTRACT

The family Pycnothelidae comprises medium to small-sized spiders that construct silk tubes under stones or logs or dig burrows in open environments. In Argentina, Acanthogonatus centralis Goloboff, 1995 and Stenoterommata platensis Holmberg, 1881 are two species commonly found in central region, associated to the mountainous grasslands or to the La Plata River Basin. The Tandilia mountainous grassland is an extended belt located southeastern Buenos Aires province, Argentina. Although some pycnothelid spiders are distributed close to this mountainous system, they are not recorded in Tandilia. Through niche modeling we attempt to evaluate the influence of bioclimatic variables in shaping the distribution of these species and explore their absence in the mountainous belt under past, present and future climatic conditions. We found that Tandilia is a non-suitable area for the establishment of the populations of these species with the exception of Stenoterommata platensis under a future scenario of climatic change.

Nicoletta, M., & Ferretti, N.. (2025). A niche modeling approach to unveil the absence of pycnothelid spiders (Mygalomorphae: Pycnothelidae) in a mountainous grassland of central Argentina. Iheringia. Série Zoologia, 115, e286369. https://doi.org/10.1590/1678-4766e286369