Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization

Posted by
  Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization Abstract Pathological corneal neovascularization remains a major therapeutic challenge due to the limited efficacy and safety of currently available antiangiogenic treatments. Although C-type lectins from snake venom possess various biological activities, their potential to modulate pathological ocular angiogenesis has not been explored. This study investigated the antiangiogenic effects of Leuculectin, a C-type lectin isolated from Bothrops leucurus venom using an experimental model of corneal neovascularization (CNV), a HUVEC (human umbilical vein endothelial cell) tube formation assay, and the chick embryo chorioallantoic membrane (CAM) assay. In the HUVEC tube formation assay, Leuculectin demonstrated strong antiangiogenic activity. In the CAM assay, Leuculectin applied at concentrations of 1.5, 2.5 and 3.5 μg/mL significantly decreased new ves...

Scorpions of the Horn of Africa (Arachnida, Scorpiones). Part XXXVII. The genus Hemiscorpius (Hemiscorpiidae)

Posted by

 


Scorpions of the Horn of Africa (Arachnida, Scorpiones). Part XXXVII. The genus Hemiscorpius (Hemiscorpiidae)

Abstract


Occurrence of the rare in the Horn of Africa genus Hemiscorpius Peters, 1861 (Scorpiones: Hemiscorpiidae) is summarized, including a distribution map. A male of Hemiscorpius lipsae Kovařík & Lowe, 2022 from Djibouti is described for the first time. A new species Hemiscorpius huluul sp. n. from Somaliland is described, fully complemented with color photographs.


Kovařík, F., Elmi, H. S., & Šťáhlavský, F. 2025 . Scorpions of the Horn of Africa (Arachnida, Scorpiones). Part XXXVII. The genus Hemiscorpius (Hemiscorpiidae). Euscorpius, No. 411: 1-24. https://mds.marshall.edu/euscorpius/vol2025/iss411/1/