Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization

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  Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization Abstract Pathological corneal neovascularization remains a major therapeutic challenge due to the limited efficacy and safety of currently available antiangiogenic treatments. Although C-type lectins from snake venom possess various biological activities, their potential to modulate pathological ocular angiogenesis has not been explored. This study investigated the antiangiogenic effects of Leuculectin, a C-type lectin isolated from Bothrops leucurus venom using an experimental model of corneal neovascularization (CNV), a HUVEC (human umbilical vein endothelial cell) tube formation assay, and the chick embryo chorioallantoic membrane (CAM) assay. In the HUVEC tube formation assay, Leuculectin demonstrated strong antiangiogenic activity. In the CAM assay, Leuculectin applied at concentrations of 1.5, 2.5 and 3.5 μg/mL significantly decreased new ves...

New distributional data for the endemic Peruvian spider Andethele huanca Coyle, 1995, with notes on morphology and biogeography (Araneae: Ischnothelidae)

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New distributional data for the endemic Peruvian spider Andethele huanca Coyle, 1995, with notes on morphology and biogeography (Araneae: Ischnothelidae)

Abstract 
The first photographs of preserved material of Andethele huanca Coyle, 1995 are presented based on a specimen collected in 2013 and deposited at the Zoological Institute of the Russian Academy of Sciences, St Petersburg, Russia. Differences in the genitalia of paratypes from disjunct localities are discussed, which may represent separate species and require further investigation. A biogeographic map, including the new locality record herein, is presented of the species under its present composition.

Bariev, Timur & Sherwood, Danniella. (2025). New distributional data for the endemic Peruvian spider Andethele huanca Coyle, 1995, with notes on morphology and biogeography (Araneae: Ischnothelidae). Acta Zoológica Lilloana. 369-374. 10.30550/j.azl/2136. 

Special thanks to Danni Sherwood for sending this publication via ResearchGate