Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

Posted by
  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Invertebrates of AlUla: Scorpions, Spiders, Dragonflies and Butterflies (Field Guide)

Posted by

 


Dear Arachnologist Friends,

It’s my pleasure to share that a field guide I co-authored—“Invertebrates of AlUla: Scorpions, Spiders, Dragonflies and Butterflies” (part of the Fauna of AlUla Field Guide Series)—has been made freely available in PDF format by the Royal Commission for AlUla (RCU).

The guide is available in both English and Arabic, with the aim of reaching a broad audience.
You’ll also find many other publications and field guides from different disciplines available at the same link.

While some taxonomic updates are already underway—particularly for the scorpions—this guide currently represents the most comprehensive and up-to-date resource for this historically important, yet previously understudied, region of the Arabian Peninsula.

The beautiful illustrations throughout the series were created by the talented Davina Falcão, who brought all the featured animals to life with her art. If interested, I leave here her website to appreciate her art! https://davinafalcaoart.com.

We warmly welcome any feedback or suggestions—and if you're interested in collaborating, there's still a lot of potential to build on this work. For that you can reach me at the email address yurisimone1@gmail.com.

A huge collective hug and see you in Croatia!

A close-up of a signature AI-generated content may be incorrect.

Yuri Simone

https://www.rcu.gov.sa/en/open-data-library