Functional characterization of antimicrobial peptides from the venom of the scorpion Chihuahuanus coahuilae
Functional characterization of antimicrobial peptides from the venom of the scorpion Chihuahuanus coahuilae
Functional characterization of antimicrobial peptides from the venom of the scorpion Chihuahuanus coahuilae Abstract Background: Antibiotic resistance is a major global health challenge driven by the declining availability of effective antimicrobials. Antimicrobial peptides (AMPs) from venomous organisms are promising alternatives because of their broad-spectrum activity and low propensity for resistance development. Chihuahuanus coahuilae , an endemic scorpion from northern Mexico, produces a venom rich in bioactive peptides with potential therapeutic applications. Methods: Venom gland transcriptomic analysis identified four novel AMP sequences, which were chemically synthesized and evaluated through structural, antimicrobial, hemolytic, cytotoxicity, and immunological assays. Antibacterial activity was assessed against clinically relevant bacterial strains, including a multidrug-resistant Acinetobacter baumannii isolate. Hemolysis was evaluated using human erythrocytes, and im...
- Get link
- X
- Other Apps