AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

Posted by
  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

First record of Euryopis scriptipes Banks, 1908 (Araneae: Theridiidae) for Hidalgo, Mexico whit data about his distribution in North America

Posted by

 


First record of Euryopis scriptipes Banks, 1908 (Araneae: Theridiidae) for Hidalgo, Mexico whit data about his distribution in North America


ABSTRACT 

Worldwide, the genus Euryopis has 81 species, its distribution is known to be cosmopolitan, 23 species of the genus are currently known in North America. This work records Euryopis scriptipes for the first time based of the review of a male and female for the state of Hidalgo, Mexico, as well providing data on its current distribution in North America. This new record expands the distribution of E. scriptipes in this biogeographical region.

Sánchez-Vega, U., Vargas , C. F. ., Callejas-Chavero, A. ., Flores-Martínez, A. y Villegas-Guzmán, G. A. . (2023) «Primer registro de Euryopis scriptipes Banks, 1908 (Araneae: Theridiidae) para Hidalgo, México con datos sobre su distribución en Norteamérica», Acta Zoológica Lilloana, 67(1), pp. 45–50. doi: 10.30550/j.azl/2023.67.1/2023-01-09.