Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

First record of Euryopis scriptipes Banks, 1908 (Araneae: Theridiidae) for Hidalgo, Mexico whit data about his distribution in North America

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First record of Euryopis scriptipes Banks, 1908 (Araneae: Theridiidae) for Hidalgo, Mexico whit data about his distribution in North America


ABSTRACT 

Worldwide, the genus Euryopis has 81 species, its distribution is known to be cosmopolitan, 23 species of the genus are currently known in North America. This work records Euryopis scriptipes for the first time based of the review of a male and female for the state of Hidalgo, Mexico, as well providing data on its current distribution in North America. This new record expands the distribution of E. scriptipes in this biogeographical region.

Sánchez-Vega, U., Vargas , C. F. ., Callejas-Chavero, A. ., Flores-Martínez, A. y Villegas-Guzmán, G. A. . (2023) «Primer registro de Euryopis scriptipes Banks, 1908 (Araneae: Theridiidae) para Hidalgo, México con datos sobre su distribución en Norteamérica», Acta Zoológica Lilloana, 67(1), pp. 45–50. doi: 10.30550/j.azl/2023.67.1/2023-01-09.