Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies

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  Antitumor activity of scorpion venom-derived peptides: A meta-analysis of preclinical studies Abstract Despite advances in cancer therapeutics, there are still challenges in improving drug toxicity and selectivity. Peptides from various venous species have recently garnered attention for their biopharmaceutical potential, particularly in cancer. The present study aimed to conduct a meta-analysis of the antitumor activity of scorpion venom-derived peptides (SVDPs) previously reported in preclinical models. The bibliographic research included original and review articles written in English published from 2015 to 2026. Studies within the scope were retrieved from the EBSCO Discovery Service, PubMed, and WIPO databases. A total of 27 articles that met the inclusion and exclusion criteria were included in this research, and the collected data were synthesized through a meta-analysis. In the included in vitro and in vivo studies, the effect of SVDPs on breast/mammary gland, cervical,...

Pikelinia schiapelliae, una nueva especie de araña de arenales de Argentina y Uruguay (Araneae: Filistatidae)

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Pikelinia schiapelliae, una nueva especie de araña de arenales de Argentina y Uruguay (Araneae: Filistatidae)

Abstract

Pikelinia schiapelliae, a new spider species from sandy habitats in Argentina and Uruguay (Araneae: Filistatidae). The genus Pikelinia is the main representative of the spider family Filistatidae in South America, with 19 named species. However, much of its diversity remains to be discovered. In this manuscript, we describe Pikelinia schiapelliae Magalhaes sp. nov. based on specimens collected in areas with Chacoan vegetation and sandy soils in the provinces of Buenos Aires, Santa Fe and Entre Ríos (Argentina) and Río Negro (Uruguay). The new species is distinguished from its congeners by the morphology of the sexual structures and by the DNA sequences of the cytochrome c oxidase subunit I gene. Through systematized sampling on Martín García Island, we observed that Pikelinia schiapelliae: (1) is more abundant in the months following the summer solstice; and (2) is more frequently found in areas of sandy soil. A phylogenetic analysis based on four molecular markers indicates that P. schiapelliae is a close relative of other species that also inhabit sandy soils, such as Pikelinia arenicola, suggesting the existence of a Pikelinia clade specialized in living in such habitats. Pikelinia arenicola, previously known only for Brazil, is recorded for the first time for Argentina and Uruguay.

Magalhaes, Ivan & Hagopián, Damián & Laborda, Álvaro & González, Alda & Scioscia, Cristina. (2024). Pikelinia schiapelliae, una nueva especie de araña de arenales de Argentina y Uruguay (Araneae: Filistatidae). 26. 155-169. 10.22179/REVMACN.26.858.