Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives

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  Scorpion Venom Peptides: From Structural Scaffolds to Therapeutic Applications—A Focus on Antioxidant Mechanisms and Translational Perspectives Abstract Scorpion venom peptides, with their stable disulfide backbone, compact structural framework, and highly selective regulation of ion channels, have long been regarded as important molecular probes in neuropharmacology. However, recent studies have revealed their potential for regulating oxidative stress, inflammation, and neuroprotection, making them a new research frontier. In this article, we focus on scorpion venom peptides as drugs, constructing an integrated knowledge framework from structural classification to clinical translation. First, scorpion venom peptides are systematically classified based on cysteine arrangement patterns and three-dimensional folding topology, and their structure–activity relationships are summarized. Based on this, the molecular mechanisms by which scorpion venom peptides regulate ion channels are ...

First historical checklist of spiders (Arachnida: Araneae) from Morocco, between 1840–2024

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First historical checklist of spiders (Arachnida: Araneae) from Morocco, between 1840–2024

Abstract

The checklist of Spiders (Araneae) of Morocco is presented for the first time, based on about two centuries of arid research (between 1840 and 2024), including an extensisve bibliographic study. This updated list includes a total of 549 species belonging to 225 genera and 46 families. A bibliographic review, as complete as possible, was compiled which to date includes 172 references, providing a database available for the first time and accessible for any future research on Moroccan spiders. This work is also the first step towards a catalog and an Atlas of this group of arachnids, which is currently being compiled and is the first of its kind in Morocco and even North Africa.



Zootaxa
Issue: Vol. 5555 No. 3: 19 Dec. 2024
Type: Article
Published: 2024-12-19
DOI: 10.11646/zootaxa.5555.3.5
Page range: 407-435