A new species and a new record of Zoicinae Lehtinen & Hippa, 1979 (Araneae: Lycosidae) from Sumatra Island, with notes on miniaturization in wolf spiders

Posted by
  A new species and a new record of Zoicinae Lehtinen & Hippa, 1979 (Araneae: Lycosidae) from Sumatra Island, with notes on miniaturization in wolf spiders Abstract A new species of wolf spider, Zoica veloxilla sp. nov., from Sumatra (Indonesia) is described based on both sexes. Lysania pygmaea Thorell, 1890 is recorded from Sumatra for the first time, and its male is illustrated and redescribed. A distribution map for Zoica and Lysania is provided. The problem of miniaturization in wolf spiders is briefly discussed. Based on an analysis of the literature, 32 minute species of wolf spiders in four subfamilies and eleven genera have been reported. The smallest wolf spider known worldwide seems to be Zoica minuta (McKay, 1979) from Australia. Omelko, M.M. & Fomichev, A.A. (2026) A new species and a new record of Zoicinae Lehtinen & Hippa, 1979 (Araneae: Lycosidae) from Sumatra Island, with notes on miniaturization in wolf spiders. Zootaxa, 5869 (2), 339–350. https://doi.o...

Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide

Posted by

 


Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide

Abstract

Voltage-gated potassium channels play a crucial role in cellular repolarization and are potential therapeutic targets in neuroinflammatory disorders and neurodegenerative diseases. This study explores Tityus bahiensis scorpion venom for neuroactive peptides. We identified the αKtx12 peptide as a potent neuroprotective agent. In SH-SY5Y cells, αKtx12 significantly enhances viability, validating its pharmacological potential. And in the animal model, we elucidate central nervous system (CNS) mechanism of αKtx12 through neuroproteomic analyses highlighting αKtx12 as a valuable tool for characterizing neuroplasticity and neurotropism, revealing its ability to elicit more physiological responses. The peptide’s potential to promote cell proliferation and neuroprotection suggests a role in functional recovery from nervous system injury or disease. This research unveils the neuroactive potential of scorpion venom-derived αKtx12’s, offering insights into its pharmacological utility. The peptide’s impact on neuronal processes suggests a promising avenue for therapeutic development, particularly in neurodegenerative conditions.

Ferreira, V. F., Vigerelli, H., Fernandes, K. R., Juliano, M. A., Nencioni, A. L., & Pimenta, D. C. (2024). Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide. Scientific Reports, 14(1), 1-13. https://doi.org/10.1038/s41598-024-79152-1