Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats

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  Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats ABSTRACT Snake venom vascular endothelial growth factors (svVEGFs) are homodimeric proteins comprising two equal subunits bound by two intermolecular disulfide bonds. The main biological effects of svVEGFs are local vasodilatation, increasing of vascular permeability, and hypotension. Barietin, a svVEGF purified from the venom of puff adder Bitis arietans , differs from other representatives of this toxin family by its shortened C-terminal amino acid sequence. No data about barietin effects on hemodynamics are available. Studying those in rats we found that barietin at a dose of 1 mg/kg significantly increased heart rate, exerting only a minor influence on blood pressure. In this respect, it differs from other svVEGFs having a significant effect on blood pressure. We aimed to find the barietin active fragment which m...

Contributions to the scorpion fauna of Iran. Part III. Records of genus Orthochirus Karsch, 1891 (Arachnida: Scorpiones: Buthidae)

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Contributions to the scorpion fauna of Iran. Part III. Records of genus Orthochirus Karsch, 1891 (Arachnida: Scorpiones: Buthidae)

Abstract

New locality records are given belonging to Orthochirus carinatus Navidpour, Kovařík, Soleglad & Fet, 2019 (Alborz Province), O. farzanpayi (Vachon & Farzanpay, 1987) (Fars, Chaharmahal and Bakhtiari and Lorestan Provinces), O. formozovi Kovařík, Fet & Yağmur, 2020 (Razavi Khorasan Province), O. gantenbeini Kovařík, Yağmur, Fet & Hussen, 2019 (Lorestan Province), O. iranus Kovařík, 2004 (Bushehr and Khuzestan Provinces), O. kucerai Kovařík & Navidpour, 2020 (Kerman Province), O. mesopotamicus Birula, 1918 (Khuzestan Province), O. navidpouri Kovařík, Yağmur, Fet & Hussen, 2019 (Ilam, Khuzestan and Lorestan Provinces), O. stockwelli (Lourenço & Vachon, 1995) (Fars and Hormozgan Provinces), O. varius Kovařík, 2004 (Fars and Kerman Provinces), O. vignolii Kovařík & Navidpour, 2020 (Yazd Province) and O. zagrosensis Kovařík, 2004 (Fars, Isfahan and Kohgiluyeh and Boyer Ahmad Provinces) in this study. Among them following records are new province records: Chaharmahal and Bakhtiari and Lorestan for O. farzanpayi; Lorestan for O. gantenbeini; Ilam O. navidpouri; Fars for O. stockwelli; Fars and Kerman for O. varius and Isfahan for O. zagrosensis. Also, maps are prepared including new and old distributional localities and coloured habitus pictures of reported species of Orthochirus in this study.

Yağmur, E.A., Mozaffari, N., Akbari, A. & Moradi, M. pp. 236-256. Serket vol. 20(3)
Contributions to the scorpion fauna of Iran. Part III. Records of genus Orthochirus Karsch, 1891 (Arachnida: Scorpiones: Buthidae).