AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

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  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

Scorpiops tangae sp. n. (Scorpiones: Scorpiopidae) from Laos

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Scorpiops tangae sp. n. (Scorpiones: Scorpiopidae) from Laos

Abstract


A new species Scorpiops tangae sp. n. is described from Laos, fully illustrated with color photos showing its morphology and habitus. Scorpiops tangae sp. n. is the only species of the genus with a combination of five characters: chelal trichobothrium Eb3 located in distal half of manus between trichobothria Dt and Est; patella of pedipalp with 11 ventral and 17 external trichobothria; fingers of pedipalps undulate in male; pedipalp movable finger with ca. 45 IAD; and chela length to width ratio 3.7 in male. In addition to morphology and hemispermatophore, we also present the information about the karyotype of S. tangae sp. n. (2n=105).

Kovařík, F., Šťáhlavský, F., & Stockmann, M. 2024 . Scorpiops tangae sp. n. (Scorpiones: Scorpiopidae) from Laos. Euscorpius, No. 399: 1-15. https://mds.marshall.edu/euscorpius/vol2024/iss399/1/