From Taxonomic Accuracy to Toxin Naming: A Welcome Dialogue in Toxicon

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  From Taxonomic Accuracy to Toxin Naming: A Welcome Dialogue in Toxicon By Luis A. Roque | Arácnido Taxonomy When I submitted my correspondence, “When tarantula venom comes from a misnamed spider: The importance of taxonomic accuracy in theraphosid toxinology,” to Toxicon , I hoped it would encourage a broader conversation. The purpose was to draw attention to a problem that benefits from the experience of people working across taxonomy, venom research, and biological databases. Dr. Volker Herzig’s response, “The need for a unified toxin nomenclature for consistent toxin naming,” is precisely the kind of engagement I hoped to see. His contribution acknowledges the importance of identifying venom-source organisms accurately while bringing another essential question into focus: How do we maintain continuity in toxin names when taxonomy and our understanding of toxin function change? Two connected challenges My original correspondence focused on the biological source of venom. In t...

Efficacy of oxygen-ozone therapy against the pro-necrotic action of Loxosceles rufescens toxic bite

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Efficacy of oxygen-ozone therapy against the pro-necrotic action of Loxosceles rufescens toxic bite

The bite of the Mediterranean recluse spider (Loxosceles rufescens Dufour, 1820, Araneae, Sicaridae) (Fig. 1A) has recently appeared in Italian news as the cause of fatal injuries that have led at least four people to death due to severe necrotic-inflammatory complications following exposure to the spider's toxic venom [1]. Following Loxosceles spiders’ bite, unless the victim has realized that the spider was close to him and due to the frequent absence of a verified culprit, a dramatic skin inflammatory and necrotic reaction can occur in rapid times, dumbfounding the victim. The reaction is known as loxoscelism and often involving phospholipases D as major components of the spider’s venom [2]. These ubiquitous group of enzymes, producing phosphatidic acid as a signaling molecule from degrading membrane phospholipids, induces an oxidative stress-mediated necrosis of tissues, for example vascular tissues [3]. Blocking the oxidative stress might be a possible therapeutical approach to halting the inflammatory necrotizing response caused by spiders of the Loxosceles genus.

Valdenassi, L., Franzini, M., Ricevuti, G., Tirelli, U., Carlo Galoforo, A., Vaiano, F., & Chirumbolo, S. (2024). Efficacy of oxygen-ozone therapy against the pro-necrotic action of Loxosceles rufescens toxic bite. International Immunopharmacology, 142, 113112. https://doi.org/10.1016/j.intimp.2024.113112