Can Scorpion Venom Peptides Be Safely Used in Cardiovascular Therapy: A Systematic Review

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  Can Scorpion Venom Peptides Be Safely Used in Cardiovascular Therapy: A Systematic Review Abstract Scorpion venom contains numerous bioactive peptides with potent cardiovascular effects, including bradykinin-potentiating peptides (BPPs), ion channel modulators, and cardioprotective molecules. These peptides show promise for conditions such as hypertension, cardiac injury, and arrhythmias. However, concerns regarding toxicity, immunogenicity, and off-target actions have limited their clinical development. This systematic review evaluates the therapeutic potential and safety of scorpion venom peptides for cardiovascular applications. A systematic search of PubMed, Scopus, Google Scholar, and Semantic Scholar identified 1,141 articles. Screening of 463 abstracts and full-text review of 446 eligible studies resulted in 17 publications meeting the inclusion criteria. Extracted data included mechanisms, efficacy, toxicity, and translational challenges. BPPs consistently demonstrated AC...

Phylogenomic placement and revision of Iranattus Prószyński, 1992 jumping spiders (Salticidae, Plexippini, Plexippina)

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Phylogenomic placement and revision of Iranattus Prószyński, 1992 jumping spiders (Salticidae, Plexippini, Plexippina)

Abstract

The jumping spider genus Iranattus Prószyński, 1992, distributed from Africa to southwestern Asia, has been placed within the Harmochirina because of their male palp structures and elongated third legs. Here, we present phylogenomic evidence that it belongs instead to the subtribe Plexippina, further supported by the presence of two coupling pockets in the female epigyne. In this study, we redescribe I. principalis (Wesołowska, 2000) and I. rectangularis Prószyński, 1992. Additionally, the female of I. rectangularis, the type species of the genus, is described for the first time, and we report its range extension east to India.

Marathe K, Tripathi R, Sudhikumar AV, Maddison WP (2024) Phylogenomic placement and revision of Iranattus Prószyński, 1992 jumping spiders (Salticidae, Plexippini, Plexippina). Zoosystematics and Evolution 100(2): 531-542. https://doi.org/10.3897/zse.100.122034