Ovophis tonkinensis envenoming presenting with severe isolated thrombocytopenia and local necrosis: A case report

Posted by
  Image Credit: iNaturalist (c) randall_f –  some rights reserved (CC BY-NC) Ovophis tonkinensis envenoming presenting with severe isolated thrombocytopenia and local necrosis: A case report Abstract Pit viper envenoming commonly causes venom-induced consumption coagulopathy with hypofibrinogenaemia. However, isolated thrombocytopenia without fibrinogen depletion is less recognised and may alter transfusion strategy. We report a confirmed  Ovophis tonkinensis  bite from northern Vietnam presenting with severe isolated thrombocytopenia and local necrosis. The case highlights the importance of serial platelet monitoring, awareness of fibrinogen availability and appropriate timing of antivenom and platelet support in resource-limited tropical settings. Duc ND, Hong Anh LN, Hong Khanh LN, Bach ND. Ovophis tonkinensis envenoming presenting with severe isolated thrombocytopenia and local necrosis: A case report. Tropical Doctor . 2026;0(0). doi: 10.1177/00494755261435153

Exploring the Therapeutic Potential of Scorpion-Derived Css54 Peptide Against Candida albicans

Posted by

 


Exploring the Therapeutic Potential of Scorpion-Derived Css54 Peptide Against Candida albicans

Abstract

Candida albicans (C. albicans) is one of the most common opportunistic fungi worldwide, which is associated with a high mortality rate. Despite treatment, C. albicans remains the leading cause of life-threatening invasive infections. Consequently, antimicrobial peptides (AMPs) are potential alternatives as antifungal agents with excellent antifungal activity. We previously reported that Css54, found in the venom of Centrurodies suffusus suffusus (C. s. suffusus) showed antibacterial activity against zoonotic bacteria. However, the antifungal activity of Css54 has not yet been elucidated. The objective of this study was to identify the antifungal activity of Css54 against C. albicans and analyze its mechanism. Css54 showed high antifungal activity against C. albicans. Css54 also inhibited biofilm formation in fluconazole-resistant fungi. The antifungal mechanism of action of Css54 was investigated using membrane-related assays, including the membrane depolarization assay and analysis of the membrane integrity of C. albicans after treatment with Css54. Css54 induced reactive oxygen species (ROS) production in C. albicans, which affected its antifungal activity. Our results indicate that Css54 causes membrane damage in C. albicans, highlighting its value as a potential therapeutic agent against C. albicans infection.

Park, J., Kim, H., Kang, D.D. et al. Exploring the Therapeutic Potential of Scorpion-Derived Css54 Peptide Against Candida albicans. J Microbiol. (2024). https://doi.org/10.1007/s12275-024-00113-4