Scorpion venom as a source of new antimicrobial agents

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  Scorpion venom as a source of new antimicrobial agents Abstract The escalating global threat of antimicrobial resistance necessitates urgent discovery of novel therapeutic agents. Scorpion venom, a complex cocktail of bioactive molecules, has emerged as a promising reservoir of antimicrobial peptides (AMPs) with potent activity against multidrug-resistant pathogens. This review comprehensively examines the structural and functional diversity of scorpion-derived AMPs and their therapeutic potential. Scorpion venom AMPs exhibit remarkable structural heterogeneity. Their physicochemical properties, characterized by cationic charge, amphipathicity, and α-helical or β-sheet conformations, underpin their antimicrobial efficacy. These peptides demonstrate broad-spectrum antimicrobial activity encompassing Gram-positive and Gram-negative bacteria, fungi, viruses, and parasites. Mechanistically, scorpion AMPs employ multifaceted strategies including membrane disruption through pore format...

Grand challenges in arachnid genetics and biomaterials

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Grand challenges in arachnid genetics and biomaterials

Arachnids, particularly spiders, flourish in abundance within most ecosystems (Blamires et al., 2007; Oxbrough and Ziesche, 2013; Henneken et al., 2022; Agnarsson, 2023; Fonseca-Ferreira et al., 2023). Arachnids such as spiders, scorpions and mites create and/or secrete a range of biomaterials, including silks, glues, adhesives, nano-fibres, venoms and other toxins, and chitin associated molecules used to form sensory systems, armour, body colouration/luminescence, and locomotion (Kuntner, 2022). Studies focusing on the evolutionary and ecological aspects of these kinds of arachnid secretory products have established that extended phenotypic features enable arachnids their immense niche flexibility (Agnarsson et al., 2010; Blamires et al., 2012a; Blamires and Tso, 2013; Blamires et al., 2017a; Blamires et al., 2017b; Lacava et al., 2018; Viera et al., 2019; Henneken et al., 2022; Kuntner, 2022). Nonetheless, the genetic features and the expression patterns implicit in facilitating this flexibility remain largely unexplored.


Blamires, S. J. (2024). Grand challenges in arachnid genetics and biomaterials. Frontiers in Arachnid Science, 3, 1356170. https://doi.org/10.3389/frchs.2024.1356170