Electrophysiological Characterization of the Venom and Toxins from the Scorpion Tityus championi Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief

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  Electrophysiological Characterization of the Venom and Toxins from the Scorpion Tityus championi Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief Abstract Scorpion neurotoxins are small peptides that target ion channels and offer opportunities for novel therapeutic discovery. This study analyzed the functional effects of the venom and toxins from the Costa Rican endemic scorpion,  Tityus championi . Initially, crude venom was tested on different isoforms of voltage-gated sodium channels. Our findings revealed that the venom contains toxins that affect mammalian Na V 1.6 and Na V 1.7, as well as the cockroach BgNa V 1 channel. Increased currents through Na V 1.6 and BgNa V 1 channels were associated with bigger window currents and inhibition of inactivation. Decreased Na V 1.7 currents were associated with smaller conductance. Crude venom and TCh3 toxin inhibited action potential generation in invertebr...

The first occurrence records of Kukulcania hibernalis (Hentz, 1842) from Ascension Island and Saint Barthélemy (Araneae: Filistatidae)

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The first occurrence records of Kukulcania hibernalis (Hentz, 1842) from Ascension Island and Saint Barthélemy (Araneae: Filistatidae)

Abstract

The Southern House Spider Kukulcania hibernalis (Hentz, 1842), native to coastal eastern Mexico and the eastern United States, is widely distributed in Central and South America, the Caribbean, and has been recorded from Liberia and the Canary Islands. Recent examination of material from Ascension Island and Saint Barthélemy newly confirm its presence as a non-native species on these islands. Kukulcania hibernalis is synanthropic, which has presumably allowed it to colonise many non-indigenous countries. In addition to reporting the new localities, we map the updated global distribution of K. hibernalis.

Sherwood, Danniella & Sharp, Adam. (2023). The first occurrence records of Kukulcania hibernalis (Hentz, 1842) from Ascension Island and Saint Barthélemy (Araneae: Filistatidae). Opuscula Zoologica. 205-209. 10.18348/opzool.2023.9.205. Danniella Sherwood via ResearchGate