Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats

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  Barietin, a snake venom vascular endothelial growth factor from puff adder Bitis arietans venom, increases the heart rate with minor effect on blood pressure in rats ABSTRACT Snake venom vascular endothelial growth factors (svVEGFs) are homodimeric proteins comprising two equal subunits bound by two intermolecular disulfide bonds. The main biological effects of svVEGFs are local vasodilatation, increasing of vascular permeability, and hypotension. Barietin, a svVEGF purified from the venom of puff adder Bitis arietans , differs from other representatives of this toxin family by its shortened C-terminal amino acid sequence. No data about barietin effects on hemodynamics are available. Studying those in rats we found that barietin at a dose of 1 mg/kg significantly increased heart rate, exerting only a minor influence on blood pressure. In this respect, it differs from other svVEGFs having a significant effect on blood pressure. We aimed to find the barietin active fragment which m...

Perioral paresthesia, generalized muscle cramps, and rhabdomyolysis following the Socotra Island Blue Baboon Tarantula (Monocentropus balfouri) bite

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Perioral paresthesia, generalized muscle cramps, and rhabdomyolysis following the Socotra Island Blue Baboon Tarantula (Monocentropus balfouri) bite

Abstract

Background

Literature on systemic envenomation caused by tarantula bites, particularly from the Theraphosidae family, is relatively scarce. This case report provides a formal description of the first known instance of systemic envenomation caused by the Socotra Island Blue Baboon Tarantula (Monocentropus balfouri).

Case Report

In this case, a 23-year-old employee of an exotic pet shop suffered from perioral paresthesia, generalized muscle cramps, and rhabdomyolysis because of a Monocentropus balfouri bite. His symptoms were successfully relieved with oral benzodiazepines. This case highlights the potential for serious complications resulting from the bite of Monocentropus balfouri, a species gaining popularity among global exotic pet collectors.


Ping, W., Keung, C. C., & Fung, W. O. (2023). Perioral paresthesia, generalized muscle cramps, and rhabdomyolysis following the Socotra Island Blue Baboon Tarantula (Monocentropus balfouri) bite. The Journal of Emergency Medicine. https://doi.org/10.1016/j.jemermed.2023.12.006