Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Prodidomus Hentz, 1847 and Zimiris Simon, 1882 on Ascension Island (Araneae: Prodidomidae)

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Prodidomus Hentz, 1847 and Zimiris Simon, 1882 on Ascension Island (Araneae: Prodidomidae)

Abstract 

A review of type material and newly collected material of the family Prodidomidae Simon, 1884 from Ascension Island is presented. Prodidomus clarki Cooke, 1964 is proposed as a junior synonym of Prodidomus rufus Hentz, 1847 syn. nov., and Prodidomus duffeyi Cooke, 1964 is deemed as a valid species but known only from a single bleached specimen, further material is needed to fully clarify its identity, The third prodidomid species on the island is confirmed as Zimiris doriae Simon, 1882.

Note: A special thank you to Danni Sherwood for sending me this publication in advance. 

Sherwood, Danniella & Sharp, Adam. (2023). Prodidomus Hentz, 1847 and Zimiris Simon, 1882 on Ascension Island (Araneae: Prodidomidae). 41. 85-92. 10.24394/NatSom.2023.41.85.