Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

First records of Clubiona hitchinsi Saaristo, 2002 on Ascension Island (Araneae, Clubionidae)

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First records of Clubiona hitchinsi Saaristo, 2002 on Ascension Island (Araneae, Clubionidae)

Abstract
Clubiona hitchinsi Saaristo, 2002, previously known from the Seychelles and French Polynesia, is newly recorded from Ascension Island, based on comparison of the Ascension specimens against two paratypes. The first detailed figures of the endogyne, based on a paratype, are provided. Characters in this species not found in European species of Clubiona Latreille, 1804 but found in the misplaced hystrix-group in Asia—namely the presence of a spine at the tip of the cymbium, retrolateral tibial apophysis with spine-like tip, and presence of a keel on the tegulum in the male, and copulatory ducts running on the posterior side in the genitalia of the female—are discussed.

Sherwood D, Marusik YM, Sharp A (2023) First records of Clubiona hitchinsi Saaristo, 2002 on Ascension Island (Araneae, Clubionidae). Check List 19(6): 833-838. https://doi.org/10.15560/19.6.833