Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

Posted by
  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

A NEW RECORD AND А TAXONOMIC REVIEW WITH CHECKLIST OF WOLF SPIDERS (ARANEAE, LYCOSIDAE) FROM IRAQ

Posted by

 


A NEW RECORD AND А TAXONOMIC REVIEW WITH CHECKLIST OF WOLF SPIDERS (ARANEAE, LYCOSIDAE) FROM IRAQ

A New Record and а Taxonomic Review with Checklist of Wolf Spiders (Araneae, Lycosidae) from
Iraq. Al-Yacoub, G. A. A., Najim, S. A. — The material in the present study was collected from two
agricultural regions in Thi-Qar and Basrah Provinces, southern Iraq. Pardosa roscai (Roewer, 1951) was
recorded for the first time from Thi Qar Province in Iraq. А list of wolf spiders (Araneae, Lycosidae) from
Iraq is presented. In addition, a map of the areas, with a taxonomic review and confirmation of five species of wolf spiders is given, with photographs of palp and epigyne of several species, which were not published in previous studies.


Al-Yacoub, G. A. A. & Najim, S. A. (2023). A new record and а taxonomic review with checklist of wolf spiders (Araneae, Lycosidae) from Iraq. Zoodiversity 57(5): 383-390. doi:10.15407/zoo2023.05.383