Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Revision of the huntsman spider genus Micrommata Latreille, 1804 (Sparassidae: Sparassinae)

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Revision of the huntsman spider genus Micrommata Latreille, 1804 (Sparassidae: Sparassinae)

Abstract The genus Micrommata Latreille, 1804 is revised and two new species are described: Micrommata biggi spec. nov. (male, female; Türkiye, Armenia, Iran, Turkmenistan), and M. diesenhoff spec. nov. (male, female; Sierra Leone). Micrommata aragonensis Urones, 2004 is synonymised with M. formosa Pavesi, 1878. All known species are redescribed and illustrated, and an identification key for males and females is provided for all true Micrommata species. A distribution map is provided for all species. M. formosa is for the first time recorded from Portugal, M. ligurina (C.L. Koch, 1845) from Morocco, the latter species having been introduced into United Kingdom and Germany. Micrommata darlingi Pocock, 1901 (female; Zimbabwe) is considered misplaced and probably related to the genus Eusparassus Simon, 1903. Functional copulatory mechanics are briefly discussed using µ-CT scans.

Jäger, P. (2023). Revision of the huntsman spider genus Micrommata Latreille, 1804 (Sparassidae: Sparassinae). Zootaxa 5352(1): 1-45. doi:10.11646/zootaxa.5352.1.1