Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Dyskinetic syndrome in tarantula spiders (Theraphosidae) (2018)

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Dyskinetic syndrome in tarantula spiders (Theraphosidae)

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ABSTRACT:

There have been increasing reports of cases of erratic movements and ataxia followed by death in tarantula species. This paper covers a brief review of what we know about the condition and what to look for in a tarantula patient. This is the first paper on this syndrome and thus hypotheses on causality and treatment options are in their infancy. The paper concludes with a call for more case reports to be published or sent to the attention of the authors such that we can continue to build on the data we already have to seek a better treatment option.

Emily Draper (RVN Cert VNES) & Steven A. Trim (BSc Cbiol MRSB) (2018) Dyskinetic syndrome in tarantula spiders (Theraphosidae), Veterinary Nursing Journal, 33:8, 230-232, DOI: 10.1080/17415349.2018.1484677