Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

A new species of Pandinus Thorell, 1876 from the Sahelian wooded steppes of Burkina Faso (Scorpiones: Scorpionidae)

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A new species of Pandinus Thorell, 1876 from the Sahelian wooded steppes of Burkina Faso (Scorpiones: Scorpionidae)


Abstract 


A new species of the genus Pandinus Thorell, 1876 is described on the basis of six males and three females collected in the Sahelian wooded steppes of Burkina Faso. The new species is mainly characterized by a small size, a reduced pectinal tooth count, a length to depth ratio of fourth metasomal segment lower than 2, a number of ventral trichobothria on pedipalp patella lower than 30, tergites and internal face of pedipalp chela almost smooth and chela manus paler than body. The new taxon described here raises the number of currently recognized species for the genus Pandinus to five and the number of known scorpion species in Burkina Faso to eight.

Ythier, Eric. (2023). A new species of Pandinus Thorell, 1876 from the Sahelian wooded steppes of Burkina Faso (Scorpiones: Scorpionidae). SERKET The Arachnological Bulletin of the Middle East and North Africa. 19. 398-411.