Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

A new electric-blue tarantula species of the genus Chilobrachys Karsh, 1892 from Thailand (Araneae, Mygalomorphae, Theraphosidae)

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A new electric-blue tarantula species of the genus Chilobrachys Karsh, 1892 from Thailand (Araneae, Mygalomorphae, Theraphosidae)

Abstract

The enchanting phenomenon of blue coloration in animals arises from the fact that blue is one of the rarest colors found in nature, and it is a structural color that is produced by the arrangement of biological photonic nanostructures, rather than pigments. This unique coloration has evolved independently in many different species, adding to the fascination and diversity of coloration patterns in the animal kingdom. This study describes a new species of Chilobrachys Karsch, 1892 from southern Thailand that exhibits a blue-violet hue resembling the color of electrical sparks. Photographic illustrations, a morphological description, and the natural habitat of the new species are given. The diagnosis, palpal-bulb structures, spermathecae, and stridulatory organ morphology of related species are discussed.

Chomphuphuang N, Sippawat Z, Sriranan P, Piyatrakulchai P, Songsangchote C (2023) A new electric-blue tarantula species of the genus Chilobrachys Karsh, 1892 from Thailand (Araneae, Mygalomorphae, Theraphosidae). ZooKeys 1180: 105-128. https://doi.org/10.3897/zookeys.1180.106278