Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Photo Identification Guide of the Atypidae (Araneae) of South Africa

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Photo Identification Guide of the Atypidae (Araneae) of South Africa

Description

The family Atypidae is known from five genera and 90 species (World Spider Catalog 2020). Only one genus, Calommata Lucas, 1837, represented by 13 species, are known from Africa and two of them from South Africa. They are very rare spiders and both of them are restricted endemics. Calommata meridionalis Fourie, Haddad & Jocqué, 2011 is listed as Near Threatened under the B criterion and Calommata transvaalica Hewitt, 1916 Vulnerable under the B criterion. CONTENTS

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