Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Insights on the diet of Buthus Leach, 1815 (Scorpiones: Buthidae) from Ouarsenis mountains of northwestern Algeria

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Insights on the diet of Buthus Leach, 1815 (Scorpiones: Buthidae) from Ouarsenis mountains of northwestern Algeria


Abstract

This study is an empirical observation of the feeding behavior of the Buthus Leach, 1815, in the wild of the Ouarsenis Mountains (Tissemsilt and Tiaret regions, Northwestern Algeria) during the study period (2021–2022). We have observed 29 instances of Buthus species eating arthropods. The identifications of this prey yielded a list of 20 species belonging to 15 families and 9 orders. We note a dominance of the Orthoptera and Coleoptera, with 3 families and 5 species for each. Gryllidae and Scarabaeidae are the most represented, with 3 and 2 species, respectively. Also, we record some insects larvae eating and many cases of cannibalism and intraguild predation. All of the Buthus species' prey are intermediate or smaller arthropods.