Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

A survey of the spider genus Ischnocolus Ausserer, 1871 (Aranei: Theraphosidae) in Israel, with description of a new species

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 A survey of the spider genus Ischnocolus Ausserer, 1871 (Aranei: Theraphosidae) in Israel, with description of a new species

ABSTRACT

The genus Ischnocolus Ausserer, 1871 is found to include three species represented in Israel: the recently described I. ignoratus Guadanucci et Wendt, 2014, I. meron sp.n. described herein, and an additional congener inhabiting the Negev Desert and known only from a subadult specimen (most likely, belonging to I. jickelii L. Koch, 1875). The new species differs from I. ignoratus as well as from other congeners by a specific configuration of the spermathecae and by integral leg tarsi I–IV lacking the transverse suture. Regarding the type series of I. ignoratus, a controversial information concering the collection data is discussed in detail. Ischnocolus meron sp.n. and I. ignoratus are diagnosed, depicted and (re)described; the data on their ecology and distribution are also provided.


Zonstein S.L. 2023. A survey of the spider genus Ischnocolus Ausserer, 1871 (Aranei: Theraphosidae) in Israel, with description of a new species // Arthropoda Selecta. Vol.32. No.2: 197–212 [in English].