Scorpion venom as a source of new antimicrobial agents

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  Scorpion venom as a source of new antimicrobial agents Abstract The escalating global threat of antimicrobial resistance necessitates urgent discovery of novel therapeutic agents. Scorpion venom, a complex cocktail of bioactive molecules, has emerged as a promising reservoir of antimicrobial peptides (AMPs) with potent activity against multidrug-resistant pathogens. This review comprehensively examines the structural and functional diversity of scorpion-derived AMPs and their therapeutic potential. Scorpion venom AMPs exhibit remarkable structural heterogeneity. Their physicochemical properties, characterized by cationic charge, amphipathicity, and α-helical or β-sheet conformations, underpin their antimicrobial efficacy. These peptides demonstrate broad-spectrum antimicrobial activity encompassing Gram-positive and Gram-negative bacteria, fungi, viruses, and parasites. Mechanistically, scorpion AMPs employ multifaceted strategies including membrane disruption through pore format...

A robust genome and assembly with transcriptomic data from the striped scorpion, Centruroides vittatus.

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 Photo Credit: By Charles & Clint - Flickr, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=1825869


A robust genome and assembly with transcriptomic data from the striped scorpion, Centruroides vittatus. 

Abstract

Scorpions, a seemingly primitive, stinging arthropod taxa, are known to exhibit marked diversity in their venom components. These venoms are known for their human pathology, but also important as models for therapeutic and drug development applications. We report a high quality genome assembly and annotation of the striped bark scorpion, Centruroides vittatus, created with several shotgun libraries. The final assembly is 760 Mb in size, with a BUSCO score of 97.8%, a 30.85% GC, and a N50 of 2.35 Mb. We estimated 36,189 proteins with 37.32% assigned to GO terms in our GOanna analysis. We were able to map 2011 and 60 venom toxin genes to contigs and scaffolds, respectively. We were also able to identify expression differences between venom gland (telson) and body tissue (carapace) with 19 Sodium toxin and 14 Potassium toxin genes to 18 contigs and two scaffolds. This assembly along with our transcriptomic data, provides further data to investigate scorpion venom genomics.

A robust genome and assembly with transcriptomic data from the striped scorpion, Centruroides vittatus
Tsunemi Yamashita, Douglas D. Rhoads, Jeff Pummill
bioRxiv 2023.08.04.551372; doi: https://doi.org/10.1101/2023.08.04.551372
This article is a preprint and has not been certified by peer review