Two new arthropod toxins purified from the venom of the Mexican scorpion Centruroides nigrescens

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  Two new arthropod toxins purified from the venom of the Mexican scorpion Centruroides nigrescens Abstract The venom of the slender black scorpion Centruroides nigrescens , from the State of Guerrero México, was fractionated by Sephadex G–50 gel filtration, followed by carboxymethyl cellulose ion separation and high–performance liquid chromatography, permitting to obtain two new peptides toxic to arthropods. The estimate LD 50 of the soluble venom for the insect Acheta domesticus was 11.1 μg/g body weight, and for the arthropod Armadillidium vulgare was 61.1 μg body weight . The amino acid sequence of toxin Cnige1 (toxic to A. domesticus and A. vulgare ) contains 65 amino acids, with a molecular mass of 7273.37 mass units, whereas toxin Cnige2, toxic to A. domesticus , contains 68 amino acids, with a molecular mass of 7548.81 units. Both peptides are well packed, containing 8 cysteines, which in the native venoms are forming 4 disulfide bridges each. The amino acid sequences f...

A Case Report on Generalised Muscle Spasms After Ornamental Tarantula Bites That Well-Responded to Intravenous Calcium Gluconate Treatment

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By Matěj Baťha - This photograph was taken with a DSLR from WMCZ's Camera grant., CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=32462389


A Case Report on Generalised Muscle Spasms After Ornamental Tarantula Bites That Well-Responded to Intravenous Calcium Gluconate Treatment


Abstract 


Here, we present a case of a 55-year-old male, who was admitted with a spider bite, which caused swelling of the hand and painful muscle spasms along with palpitations. The patient made a complete recovery after the administration of intravenous calcium gluconate, followed by oral calcium supplements. Although no specific treatment exists in Sri Lanka for spider bites, calcium supplements can be beneficial for Sri Lankan ornamental tarantula (Poecilotheria fasciata) bites.

Ramesh R, Kanagasingam A, Anushanth U, et al. (August 07, 2023) A Case Report on Generalised Muscle Spasms After Ornamental Tarantula Bites That Well-Responded to Intravenous Calcium Gluconate Treatment. Cureus 15(8): e43074. doi:10.7759/cureus.43074