Venom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndromeVenom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndrome

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  Venom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndromeVenom induced pressure elevation reversible syndrome: a severe pediatric rattlesnake envenomation, evidence for conservative management, and call for naming the syndrome Abstract Introduction : Rattlesnake envenomation frequently mimics traumatic compartment syndrome, as both are characterized by severe pain, swelling, and elevated compartment pressures. Unlike traumatic compartment syndrome there have been no documented cases of ischemic limb injury after envenomated patients have received antivenom. Furthermore, there is experimental evidence that fasciotomy worsens myonecrosis. This has led medical toxicologists and surgical guidelines to shift from liberally recommending fasciotomy to near universal recommendation of antivenom alone. Despite this, fasciotomies continue to be recommended and performed on rattle...

Snake Venom and Envenomation: From Molecular Insights to Clinical Translation (Call for Submissions)

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Snakebite envenomation remains a major neglected tropical disease with significant global health impact, particularly in low- and middle-income countries. This Collection aims to showcase multidisciplinary research on snake venoms and envenomation, integrating molecular and omics-based characterisation of venom components with mechanistic, preclinical, and clinical insights into toxin-induced pathology.

The Collection welcomes original research, reviews, and translational studies covering venomics, proteomics, metabolomics, mechanisms of envenomation, antivenom development, innovative therapeutic strategies, and public health perspectives. Emphasis is placed on bridging fundamental venom biology with clinical translation and real-world impact in snakebite management.

Journal: Discover Life