An integrative description of Euscorpius diagorasi sp. n. from Rhodes, Greece (Scorpiones: Euscorpiidae)

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  An integrative description of Euscorpius diagorasi sp. n. from Rhodes, Greece (Scorpiones: Euscorpiidae) Abstract The genus  Euscorpius  Thorell, 1876 comprises a diverse and taxonomically challenging group of scorpions in the Mediterranean, with Greece representing one of its principal centers of diversity. In this study, we provide an integrative description of  Euscorpius diagorasi   sp. n. , a new species from Rhodes Island, Greece. The new species is described on the basis of adult male and female morphology and mitochondrial COI sequence data. It is a small oligotrichous species characterized by a total length of approximately 21–25 mm, pale yellow to light brown coloration with darker reddish-brown pedipalps, pectinal tooth count of 8 in the male and 7 in the females, Pv = 7–8, Pe-et = 5–6, and a distinct mitochondrial lineage. Phylogenetic analyses based on COI recovered the Rhodian specimens as a strongly supported monophyletic lineage, sister to...

Snake Venom Meets Oncology: Unraveling the Anticancer Potential of Crotamine

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By Leandro Avelar - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=49733700

Snake Venom Meets Oncology: Unraveling the Anticancer Potential of Crotamine

Abstract

Cancer remains a significant global health challenge, prompting the search for novel therapeutic strategies that minimize the limitations of current treatments. Crotamine, a cationic myotoxin isolated from the venom of Crotalus durissus spp., has emerged as a promising anticancer candidate due to its selective cytotoxicity toward tumor cells and multifaceted biological activities. This review examines the structural and functional characteristics of crotamine, emphasizing its mechanisms of action, such as disruption of ionic homeostasis through calcium influx, inhibition of voltage-gated potassium channels (Kv), and its preferential uptake by proliferating cells as a cell-penetrating peptide (CPP). Moreover, crotamine facilitates the intracellular delivery of bioactive compounds, enhancing drug selectivity and efficacy. Preclinical studies have demonstrated its ability to inhibit tumor growth both in vitro and in vivo, with minimal toxicity to normal tissues and low immunogenicity. These features position crotamine as a strong candidate for anticancer drug development. However, further investigation is essential to fully elucidate its molecular targets and mechanisms and to support its clinical translation.
Jacob, B., Alberghini-dos-Santos, J., Ferreira, I., Vieira, B., Malachias-Pires, G., Cerni, F., Pucca, M., Arantes, E., & Oliveira, I. (2025). Snake Venom Meets Oncology: Unraveling the Anticancer Potential of Crotamine. Toxicon, 108670. https://doi.org/10.1016/j.toxicon.2025.108670