Letter: Description of Two Cases of Spider Bites Attributed to Loxosceles rufescens (Araneae, Sicariidae) in Albania

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  Letter: Description of Two Cases of Spider Bites Attributed to Loxosceles rufescens (Araneae, Sicariidae) in Albania Fewer than 0.5% of spider species are medically significant, with the genus  Loxosceles  responsible for most dermonecrotic envenomings. 1 , 2  In the Mediterranean,  Loxosceles rufescens  is the primary species associated with loxoscelism. 2  This synanthropic spider thrives in human dwellings, typically biting only when inadvertently provoked. 1 , 3 , 4  Its venom, containing sphingomyelinase D, triggers local inflammation and necrosis, 1 , 5  and rarer the acute localized exanthematous pustulosis. 6  Diagnosis is often challenged by initial painlessness, leading to frequent misidentification as bacterial infections. 2 , 4 , 5  These cases in Albania highlight the need for improved clinical recognition of regional spider-bite occurrences. 7 Two cases were retrospectively documented via interviews and photos. Infor...

Fatal Bothrops atrox snakebite with thrombotic microangiopathy, hemorrhagic stroke and acute kidney injury

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By Darío De la Fuente - https://www.inaturalist.org/photos/113840233, CC BY 4.0, https://commons.wikimedia.org/w/index.php?curid=129474300

Fatal Bothrops atrox snakebite with thrombotic microangiopathy, hemorrhagic stroke and acute kidney injury

Abstract

Bothrops atrox is responsible for most snakebite envenomations in the Amazon region. Its venom induces systemic hemostatic disturbances and local tissue damage, potentially leading to severe complications. This report describes a fatal case of B. atrox envenomation in a 53-year-old male with a history of hypertension and alcoholism. The patient presented with persistent incoagulable blood, thrombocytopenia, anemia, and progressive renal dysfunction. These findings were consistent with venom-induced consumption coagulopathy (VICC) associated with thrombotic microangiopathy (TMA). He subsequently developed intracranial hemorrhage, the autopsy revealed a confirmed subarachnoid hemorrhage, and acute kidney injury (AKI), which contributed to systemic decompensation. Postmortem findings included subarachnoid hemorrhage, acute tubular necrosis, hepatic steatosis, and fibrin thrombi in cutaneous vessels. This case highlights the potential for severe systemic involvement in Bothrops atrox envenomation, particularly in patients with preexisting comorbidities, and underscores the need for early recognition of complications such as VICC and TMA to guide appropriate clinical management.
Duarte, L. R. A., Carvalho, É., Melo, T. F. C., Barbosa, F. B. A., De Andrade, R. V., Sartim, M., Araújo, F. Q., Sachett, J., Pivoto, G., De Lima Ferreira, L. C., & Monteiro, W. (2025). Fatal Bothrops atrox snakebite with thrombotic microangiopathy, hemorrhagic stroke and acute kidney injury. Toxicon, 268, 108610. https://doi.org/10.1016/j.toxicon.2025.108610