From Taxonomic Accuracy to Toxin Naming: A Welcome Dialogue in Toxicon

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  From Taxonomic Accuracy to Toxin Naming: A Welcome Dialogue in Toxicon By Luis A. Roque | Arácnido Taxonomy When I submitted my correspondence, “When tarantula venom comes from a misnamed spider: The importance of taxonomic accuracy in theraphosid toxinology,” to Toxicon , I hoped it would encourage a broader conversation. The purpose was to draw attention to a problem that benefits from the experience of people working across taxonomy, venom research, and biological databases. Dr. Volker Herzig’s response, “The need for a unified toxin nomenclature for consistent toxin naming,” is precisely the kind of engagement I hoped to see. His contribution acknowledges the importance of identifying venom-source organisms accurately while bringing another essential question into focus: How do we maintain continuity in toxin names when taxonomy and our understanding of toxin function change? Two connected challenges My original correspondence focused on the biological source of venom. In t...

Anti-Toxoplasma gondii studies of the venom peptide XYP4 from the Lycosa coelestis

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Anti-Toxoplasma gondii studies of the venom peptide XYP4 from the Lycosa coelestis

Abstract

Toxoplasma gondii (T. gondii) is an intracellular parasite with multiple routes of infection that poses a serious health risk to pregnant women, fetuses, and immunocompromised populations. Currently, clinical drugs in the treatment of toxoplasmosis continue to face challenges such as drug resistance. In the face of this challenge, researchers have gradually focused on the potential medicinal value of animal venoms in the fight against T. gondii, especially venom peptides showing advantages such as high potency, membrane targeting, and immunomodulation. The present study aimed to explore whether XYP4, a peptide derived from the venom of the Lycosa coelestis (L. coelestis), possesses better anti-T. gondii activity and its mode of action. The experimental results showed that XYP4 is an amphiphilic cationic linear polypeptide with an α-helix, which can exert anti-toxoplasma activity at low concentrations, affecting the lytic cycle. This polypeptide showed moderate survival benefits in mice infected with T. gondii. The main modes of action of XYP4 include inhibition of tachyzoites' intracellular proliferation, modulation of inflammatory factor expression in the host cells, and disruption of tachyzoite membrane integrity.
Yang, D., Liu, X., Li, J., Wu, K., Xie, J., Wang, Y., Wang, Z., & Jiang, L. (2025). Anti-Toxoplasma gondii studies of the venom peptide XYP4 from the Lycosa coelestis. Toxicon, 108540. https://doi.org/10.1016/j.toxicon.2025.108540