Inter-individual variability in equine antibody responses to African snake venoms follows heavy-tailed distributions with implications for antivenom production

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  Inter-individual variability in equine antibody responses to African snake venoms follows heavy-tailed distributions with implications for antivenom production Abstract Variability in the antibody response of horses used for snake antivenom manufacture is well recognized, yet its statistical structure and implications for industrial productivity remain poorly characterized. In this study, we quantified antivenom antibody titers by ELISA in a cohort of 14 horses immunized with venoms from the clinically most important snakes in sub-Saharan Africa. To integrate antibody levels with plasma availability, we calculated the Cumulative Plasma Productivity (CPP) by converting individual plasma volumes into titer-corrected equivalents and sequentially pooling these volumes according to their corrected contribution. Distributional analysis revealed right-skewed, heavy-tailed patterns better approximated by a log-normal model than by a strict Pareto (power-law) form, with approximately 20–3...

The magnitude of legal wildlife trade and implications for species survival

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The magnitude of legal wildlife trade and implications for species survival

The unsustainable use of wildlife is a primary driver of global biodiversity loss. No comprehensive global dataset exists on what species are in trade, their geographic origins, and trade's ultimate impacts, which limits our ability to sustainably manage trade. The United States (US) is one of the world's largest importers of wildlife, trade data being compiled in the US Law Enforcement Management Information System (LEMIS), the only comprehensive publicly-accessible wildlife trade database of non-CITES listed species. In total, 21,097 species and over 2.85 billion individuals were traded over the past 22 years (2000-2022). When LEMIS data is combined with CITES records, the US imported over 29,445 wild species, including over 50% of all globally described species in some taxonomic groups. For most taxa, around half of the individuals are declared as sourced from the wild. Although LEMIS provides the only means to assess trade volumes for many taxa, without any associated data on most wild populations, it is impossible to assess the impact or sustainability of trade, or any potential risk of pest or pathogen spread. Furthermore, these insights underscore the likely under-estimation of trade, and the urgent need for other countries to adopt similar mechanisms to accurately record trade.


Alice Hughes, Benjamin Marshall, Aubrey Alamshah et al. The magnitude of legal wildlife trade and implications for species survival, 30 January 2024, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-3890407/v1]