Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Three new species of the giant vinegaroon genus Mastigoproctus (Thelyphonida: Thelyphonidae) from Mexico

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Three new species of the giant vinegaroon genus Mastigoproctus (Thelyphonida: Thelyphonidae) from Mexico

Abstract

The giant vinegaroons of the genus MastigoproctusPocock, 1894 have been the subject of recent investigations aimed at elucidating relationships between their species and their validity. In particular, new data have revealed the presence of new species as well as revalidated species that were previously considered as synonyms of Mastigoproctus giganteus (Lucas, 1835). The genus occurs in southern USA, Mexico and South America. In this paper, we describe three additional new species from Mexico: M. franckei Barrales-Alcalá, sp. nov. from Xilitla, San Luis Potosí, M. xetame Barrales-Alcalá & Francke, sp. nov. from the highlands of Jalisco and M. yalchanchak Barrales-Alcalá & Francke, sp. nov. from La Esperanza, Chiapas. The present contribution raises the diversity of the order Thelyphonida in Mexico to 10 species.

Diego Alejandro Barrales-Alcalá, Oscar F. Francke "Three new species of the giant vinegaroon genus Mastigoproctus (Thelyphonida: Thelyphonidae) from Mexico," The Journal of Arachnology, 51(2), 223-237, (6 October 2023)