Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders

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  By 4028mdk09 - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=11200575 Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders Abstract The puff adder ( Bitis arietans ) is a highly venomous viper responsible for many snakebite fatalities in Africa, yet there have been few geographically comprehensive analyses of its venom proteins, particularly of the proteases that play a key role in pathology of envenoming. To address this, we have isolated, identified and characterised the bioactivity of the venom metalloproteases of puff adders obtained from a range of localities. Prominent in all venoms was a PI snake venom metalloproteinase (SVMP), derived from a larger PII precursor. This protein existed as either non-glycosylated (21 kDa) or glycosylated, the latter containing either one (26 kDa) or two N-glycans (30 kDa). All the venoms we tested contained either one or the other form: none had...

Global Arthropod beta-diversity is spatially and temporally structured by latitude

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Global Arthropod beta-diversity is spatially and temporally structured by latitude

Aim: Global gradients in species biodiversity may or may not be associated with greater species replacement closer to the equator. Yet, empirical validation of these patterns has so far focused on less diverse taxa, with comparable assessments of mega-diverse groups historically constrained by the taxonomic impediment.

Mathew Seymour, Tomas Roslin, Jeremy deWaard et al. Global Arthropod beta-diversity is spatially and temporally structured by latitude, 22 September 2023, PREPRINT (Version 2) available at Research Square [https://doi.org/10.21203/rs.3.rs-2180975/v2]